The International HIV Dementia Scale: a new rapid screening test for HIV dementia

dc.contributor.author Sacktora, Ned C.
dc.contributor.author Wong, Matthew
dc.contributor.author Nakasujja, Noeline
dc.contributor.author Skolasky, Richard L.
dc.contributor.author Selnes, Ola A.
dc.contributor.author Musisi, Seggane
dc.contributor.author Robertson, Kevin
dc.contributor.author McArthur, Justin C.
dc.contributor.author Ronald, Allan
dc.contributor.author Katabira, Elly
dc.date.accessioned 2011-12-15T16:55:05Z
dc.date.available 2011-12-15T16:55:05Z
dc.date.issued 2005
dc.description.abstract Objective: HIV dementia is an important neurological complication of advanced HIV infection. The use of a cross-cultural screening test to detect HIV dementia within the international community is critical for diagnosing this condition. The objective of this study was to evaluate the sensitivity and specificity of a new screening test for HIV dementia, the International HIV Dementia Scale (IHDS) in cohorts from the US and Uganda. Design: Two cross-sectional cohort studies designed to evaluate for the presence of HIV dementia. Methods: Sixty-six HIV-positive individuals in the US and 81 HIV-positive individuals in Uganda received the IHDS and full standardized neurological and neuropsychological assessments. The sensitivity and specificity of varying cut-off scores of the IHDS were evaluated in the two cohorts. Results: In the US cohort, the mean IHDS score for HIV-positive individuals without dementia and with dementia were 10.6 and 9.3 respectively (P < 0.001). Using the cutoff of 10, the sensitivity and specificity for HIV dementia with the IHDS were 80% and 57% respectively in the US cohort, and 80% and 55% respectively in the Uganda cohort. Conclusions: The IHDS may be a useful screening test to identify individuals at risk for HIV dementia in both the industrialized world and the developing world. Full neuropsychological testing should then be performed to confirm a diagnosis of HIV dementia. en_US
dc.identifier.citation Sacktora, N. ,Wong, M.,Nakasujja, N., e tal. The International HIV Dementia Scale: a new rapid screening test for HIV dementia Vol 19 No 13 en_US
dc.identifier.issn 0269-9370
dc.identifier.issn 1473-5571
dc.identifier.uri http://hdl.handle.net/10570/257
dc.language.iso en en_US
dc.publisher Lippincott Williams & Wilkins en_US
dc.subject HIV en_US
dc.subject Dementia en_US
dc.subject Screening test en_US
dc.subject Uganda en_US
dc.subject International en_US
dc.subject Scale en_US
dc.title The International HIV Dementia Scale: a new rapid screening test for HIV dementia en_US
dc.type Journal article, peer reviewed en_US
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