Stochastic model for Langerhans Cells and HIV dynamics: In vivo

dc.contributor.author Mbogo R., Waema
dc.contributor.author Luboobi, Livingstone S
dc.contributor.author Odhiambo, John W.
dc.date 2014
dc.date.accessioned 2015-09-23T11:37:32Z
dc.date.available 2015-09-23T11:37:32Z
dc.description.abstract Many aspects of the complex interaction between HIV and the human immune system remain elusive.Our objective is to study these interactions, focusing on the specific roles of Langerhans cells (LCs) in HIV infection. In patients infected with HIV, a large amount of virus is associated with LCs in lymphoid tissue. To assess the influence of LCs on HIV viral dynamics during antiretroviral therapy, we present and analyse a stochastic model describing the dynamics of HIV, CD+4 T-cells, and LCs interactions under therapeutic intervention in vivo and show that LCs play an important role in enhancing and spreading initial HIV infection. We perform sensitivity analyses on the model to determine which parameters and/or which interaction mechanisms strongly affect infection dynamics.
dc.identifier.citation Mbogo, R.W., Luboobi, L.S., Odhiambo, J.W. (2014). Stochastic model for Langerhans Cells and HIV dynamics: In vivo. ISRN Applied Mathematics
dc.identifier.uri http://hdl.handle.net/10570/4554
dc.identifier.uri http://dx.doi.org/10.1155/2014/594617
dc.language English
dc.publisher Hindawi Publishing Corporation
dc.subject HIV/AIDS
dc.subject CD+4 T cells
dc.subject HIV infection
dc.title Stochastic model for Langerhans Cells and HIV dynamics: In vivo en_US
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