Low prevalence of pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia

dc.contributor.author Taylor, Steve, M.
dc.contributor.author Meshnick, Steven, R.
dc.contributor.author Worodria, William
dc.contributor.author Andama, Alfred
dc.contributor.author Davis, J. Lucian
dc.contributor.author Cattamanchi, Adithya
dc.contributor.author Den Boon, Saskia
dc.contributor.author Yoo, Samuel D.
dc.contributor.author Goodman, Carol D.
dc.contributor.author Huang, Laurence
dc.date.accessioned 2012-11-14T08:38:36Z
dc.date.available 2012-11-14T08:38:36Z
dc.date.issued 2012-02-15
dc.description.abstract Pneumocystis jirovecii is an important opportunistic infection in human immunodeficiency virus (HIV)–infected patients. In the developed world, P. jirovecii epidemiology is marked by frequent colonization in immunosuppressed patients, but data on the prevalence of colonization are very limited in sub-Saharan Africa, where the majority of persons living with HIV reside. Our objective was to describe the epidemiology of P. jirovecii colonization among HIV-positive patients in a cross-sectional, hospital-based study of patients admitted with suspected pneumonia in Kampala, Uganda. P. jirovecii was detectable in bronchoalveolar lavage fluid from 7 (6%) of 124 consecutive patients with non-Pneumocystis pneumonia. Colonization was not associated with patient demographic or clinical information. This prevalence is substantially lower than in published studies in the developed world and suggests that there is a limited reservoir of organisms for clinical infections in this Ugandan population. These findings may partially explain the low incidence of Pneumocystis pneumonia in Uganda and other sub-Saharan African countries. en_US
dc.description.sponsorship This work was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health (K24 HL087713 and R01 HL090355-04 to L.H.) and by the National Institute of Allergy and Infectious Diseases (K23 AI080147 to J.L.D.). en_US
dc.identifier.citation Taylor, S. M. et al. (2012). Low prevalence of pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia. Diagnostic Microbiology and Infectious Disease, 72: pp. 139-143 en_US
dc.identifier.issn 0732-8893
dc.identifier.uri www.sciencedirect.com
dc.identifier.uri http://hdl.handle.net/10570/865
dc.language.iso en en_US
dc.publisher SciVerse ScienceDirect en_US
dc.subject Pneumocystis jirovecii en_US
dc.subject Colonization en_US
dc.subject Pneumonia en_US
dc.subject AIDS en_US
dc.title Low prevalence of pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia en_US
dc.type Journal article, peer reviewed en_US
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