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    Low prevalence of pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia

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    Steve M Taylor-IDI-Res1.pdf (163.9Kb)
    Date
    2012-02-15
    Author
    Taylor, Steve, M.
    Meshnick, Steven, R.
    Worodria, William
    Andama, Alfred
    Davis, J. Lucian
    Cattamanchi, Adithya
    Den Boon, Saskia
    Yoo, Samuel D.
    Goodman, Carol D.
    Huang, Laurence
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    Abstract
    Pneumocystis jirovecii is an important opportunistic infection in human immunodeficiency virus (HIV)–infected patients. In the developed world, P. jirovecii epidemiology is marked by frequent colonization in immunosuppressed patients, but data on the prevalence of colonization are very limited in sub-Saharan Africa, where the majority of persons living with HIV reside. Our objective was to describe the epidemiology of P. jirovecii colonization among HIV-positive patients in a cross-sectional, hospital-based study of patients admitted with suspected pneumonia in Kampala, Uganda. P. jirovecii was detectable in bronchoalveolar lavage fluid from 7 (6%) of 124 consecutive patients with non-Pneumocystis pneumonia. Colonization was not associated with patient demographic or clinical information. This prevalence is substantially lower than in published studies in the developed world and suggests that there is a limited reservoir of organisms for clinical infections in this Ugandan population. These findings may partially explain the low incidence of Pneumocystis pneumonia in Uganda and other sub-Saharan African countries.
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    www.sciencedirect.com
    http://hdl.handle.net/10570/865
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