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Genetic polymorphisms in plasmodium falciparum associated with resistance to artemisinin combination therapy: complexity of infection during short-term culture and characterization of in vitro sensitivity in Kampala Uganda
Nsobya, Samuel Lubwama (Makerere University, 2010)Background: Artemisinin-based combination therapy (ACT) is currently advocated in Africa as a means of improving treatment efficacy and slowing the development of drug resistance. However, the selection of resistant ... -
Genetic polymorphisms in plasmodium falciparum associated with resistance to artemisnin combination therapy: complexity of infection during short-term culture and characterization of in-vitro sensitivity in Kampala Uganda
Nsobya, Samuel Lubwama (2010)Background Artemisinin-based combination therapy (ACT) is currently advocated in Africa as a means of improving treatment efficacy and slowing the development of drug resistance. However, the selection of resistant parasites, ... -
Complexity of plasmodium falciparum clinical samples from Uganda during short-term culture.
Nsobya, Samuel L.; Kiggundu, Moses; Joloba, Moses; Dorsey, Grant; Rosentha, Philip J. (University of Chicago Press, 2008-08-22)We cultured Plasmodium falciparum parasites from 98 Ugandan children with malaria and determined the complexity of infection (COI) on the basis of msp-2 polymorphisms daily for 9 days. The mean COI decreased during culture ...