Infectious Diseases Institute (IDI)
Recent Submissions
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Gastrointestinal cryptococcoma – Immune reconstitution inflammatory syndrome or cryptococcal relapse in a patient with AIDS?
(Elsevier, 2015)The introduction of antiretroviral therapy (ART) may lead to unusual paradoxical and unmasking presentations of opportunistic infections. Intra-abdominal cryptococcosis is a rare manifestation of Cryptococcus. We present ... -
Predictors and outcomes of mycobacteremia among HIV-infected smear- negative presumptive tuberculosis patients in Uganda
(BioMed Central Infectious Diseases, 2015)Background: Sputum smear microscopy for tuberculosis (TB) diagnosis lacks sensitivity in HIV-infected symptomatic patients and increases the likelihood that mycobacterial infections particularly disseminated TB will be ... -
Evaluation of four chemotherapy regimens for treatment of advanced AIDS-associated Kaposi Sarcoma in Kenya: A cost-effectiveness analysis
(Elsevier, 2022)Background The most effective treatment for advanced AIDS-associated Kaposi sarcoma is paclitaxel or pegylated liposomal doxorubicin (PLD); neither is routinely used in sub-Saharan Africa due to limited availability and ... -
Telling the story of intersectional stigma in HIV-associated Kaposi’s sarcoma in Western Kenya: A convergent mixed-methods approach
(Wiley Online Library, 2022)Introduction: The experience of stigma can be multifaceted for people with HIV and cancer. Kaposi’s sarcoma (KS), one of the most common HIV-associated cancers in sub-Saharan Africa, often presents with visible skin lesions ... -
Barriers and facilitators to chemotherapy initiation and adherence for patients with HIV-associated Kaposi’s sarcoma in Kenya: A qualitative study
(BMC, 2022)Background: Kaposi sarcoma is one of the most prevalent HIV‑associated malignancies in sub‑Saharan Africa and is often diagnosed at advanced stage of disease. Only 50% of KS patients who qualify for chemotherapy receive ... -
Viral load status before switching to dolutegravir-containing antiretroviral therapy and associations with Human Immunodeficiency Virus treatment outcomes in Sub-Saharan Africa
(Oxford University Press, 2021)Background. Dolutegravir is being rolled out globally as part of preferred antiretroviral therapy (ART) regimens, including among treatment-experienced patients. The role of viral load (VL) testing before switching patients ... -
Understanding diagnostic delays for kaposi sarcoma in Kenya: A qualitative study
(2022)Background: Although HIV-associated Kaposi sarcoma (KS) is frequently diagnosed at an advanced stage in sub-Saharan Africa, reasons for diagnostic delays have not been well described. Methods: We enrolled patients >18 years ... -
Efficacy and safety of dolutegravir or darunavir in combination with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection (NADIA): week 96 results from a prospective, multicentre, open-label, factorial, randomised, non-inferiority trial
(Elsevier, 2022-04-20)Background WHO guidelines recommend dolutegravir plus two nucleoside reverse transcriptase inhibitors (NRTIs) for second-line HIV therapy, with NRTI switching from first-line tenofovir to zidovudine. We aimed to ... -
Feasibility of virtual reality based training for optimising COVID-19 case handling in Uganda
(BMC Medical Education, 2022)Background: Epidemics and pandemics are causing high morbidity and mortality on a still-evolving scale exemplifed by the COVID-19 pandemic. Infection prevention and control (IPC) training for frontline health workers is ... -
A training for health care workers to integrate hepatitis B care and treatment into routine HIV care in a high HBV burden, poorly resourced region of Uganda: the ‘2for1’ project.
(BMC Medical Education, 2022)Introduction: The “2for1” project is a demonstration project to examine the feasibility and effectiveness of HBV care integrated into an HIV clinic and service. An initial phase in implementation of this project was the ... -
Using Intervention Mapping methodology to design an HIV linkage intervention in a refugee settlement in rural Uganda.
(AIDS Care, 2022)Nearly 80 million people have been forcibly displaced by persecution, violence, and disaster. Displaced populations, including refugees, face health challenges such as resource shortages, food and housing insecurity, ... -
Surgical site infections after neurosurgical procedures at Mulago National Referral Hospital; prevalence and bacteriological patterns
(Makerere University, 2017)Introduction ABSTRACT Surgical site infections (SSIs) remain a major cause of morbidity and mortality. They also cause high financial burden in healthcare systems worldwide. The development of postoperative surgical ... -
T cell immune responses towards plasmodium falciparum and Schistosoma mansoni co-infection in school going children along lake Victoria shoreline, Mayuge district
(2017-07)Background: T cell immune response is a major component of adaptive immune response system. Immune memory is developed when T helper cells are involved, both Plasmodium falciparum and Schistosoma mansoni infections initiate ... -
Awareness and acceptability of sickle cell screening among youth attending outpatient department, Soroti regional referral hospital, eastern Uganda
(Makerere University, 2016-05)Background: The morbidity and mortality rate of SCD is of a global concern particularly in developing countries. Therefore screening for sickle cell and genetic counseling before child bearing may be helpful in the ... -
Prevalence and factors associated with pulmonary tuberculosis among children 5-15 years attending six health centres in Kampala city
(2015)Introduction: Uganda is 19th of 22 high TB burden countries yet childhood TB is neglected; lagging TB contact tracing, poor recording and reporting with notification mainly based on smear results. With the high burden of ... -
Factors influencing frequency and timing of antenatal clinic attendance among women attending post natal care in two government health facilities in Makindye Division, Kampala District
(Makerere University, 2014-10)Antenatal care is care given to a pregnant woman to ensure safe pregnancy, labour and delivery of her child. Early, timely and frequent antenatal care attendance during pregnancy is important in identifying, preventing and ... -
Factors associated with fruit and vegetable intake among adults in Kasubi Parish, Kampala
(Makerere University, 2015-08)Introduction and background: Regular and optimal consumption of fruit and vegetables is associated with promoting good health and preventing or alleviating diseases. Globally there is low consumption of fruit and vegetables ... -
Knowledge of, attitudes towards and factors associated with diabetes mellitus prevention practices among adults (18-35 years) in Kampala Central Division, Uganda
(Makerere University, 2015-01)Introduction: Non Communicable Diseases including Diabetes are the leading cause of mortality in the world In Uganda in 1972, only 254 people were diagnosed. In 2009, the prevalence was at about 1.5 million. This emerging ... -
Prevalence and factors associated with diarrhoea among children under five years in Nyumanzi Refugee Settlement Camp Adjumani District, Uganda
(Makerere University, 2015-10)Background: Diarrhoea remains a major cause of mortality in children under five years of age in African refugees’ settlement camps. Broadly recognized risk factors for diarrhoeal diseases include little or no access to ... -
Prevalence and factors associated with malnutrition among adult Tuberculosis patients attending the national referral tuberculosis program clinic at Mulago Hospital
(Makerere University, 2015-05)Malnutrition is the major cause of morbidity for all age groups, accounting for 11 percent of the disease burden globally. According to the Uganda Demographic and Health Survey (UDHS), 19 percent of the Ugandan population ...
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