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Trypanosoma brucei rhodesiense Transmitted by a Single Tsetse Fly Bite in Vervet Monkeys as a Model of Human African Trypanosomiasis

John K., Thuita; John M., Kagira; David, Mwangangi; Enock, Matovu; Turner, M. R.; Daniel, Masiga (Public Library of Science, 2008-05)

We have investigated the pathogenicity of tsetse (Glossina pallidipes)-transmitted cloned strains of Trypanosoma brucei rhodesiense in vervet monkeys. Tsetse flies were confirmed to have mature trypanosome infections by ...

Genotypic Status of the TbAT1/P2 Adenosine Transporter of Trypanosoma brucei gambiense Isolates from Northwestern Uganda following Melarsoprol Withdrawal

Kazibwe, Anne J. N.; Nerima, Barbara; de Koning, Harry P.; Maser, Pascal; Barrett, Michael P.; Matovu, Enock (Public Library of Science, 2009-09)

Background: The development of arsenical and diamidine resistance in Trypanosoma brucei is associated with loss of drug uptake by the P2 purine transporter as a result of alterations in the corresponding T. brucei adenosine ...