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Associations between plasmodium falciparum aminoquinoline resistance genotypes and clinical presentations of malaria in Ugandan children, A case control study of Jinja District and the neighbouring Busoga Sub-Region Districts
(Makerere University, 2023-01)
Plasmodium falciparum resistance mutations to aminoquinoline antimalarials are
selected by prior drug use and may alter parasite fitness yet their associations with
clinical malaria presentations are uncertain. ...
The role of hyperferritinaemia in pediatric severe malaria pathogenesis and kidney injury
(Makerere University, 2023-01)
Ferritin, a highly conserved iron storage protein that sequesters iron from pathogens including Plasmodium falciparum, is part of the acute phase response in malaria pathogenesis. Ferritin levels are elevated in severe ...
Malaria drug resistance and associated diagnostic failures in arriving refugee children at Adjumani and Kyangwali Reception Centres in Uganda
(Makerere University, 2024)
Malaria, caused by Plasmodium falciparum (Pf), is one of the most important infections in African children and a leading cause of morbidity and mortality among refugees in sub-Saharan Africa. Uganda is one of the largest ...
Association between malaria preventive treatment regimens in pregnancy and plasmodium falciparum drug resistance mediating polymorphisms in Busia district, Eastern Uganda
(Makerere University, 2020-06)
Intermittent preventive treatment in pregnancy (IPTp) with monthly sulfadoxine-pyrimethamine (SP) is recommended for malaria-endemic parts of Africa, but efficacy is compromised by resistance and, in recent trials, ...