Search
Now showing items 11-20 of 20
Low-abundance drug resistant variant patterns among HIV-1 patients with virological failure in Uganda
(Makerere University, 2022-03)
Background: The emergence and spread of antiretroviral drug resistant HIV-1 variants is one
of the major factors responsible for therapeutic failure in persons living with HIV (PLWH) as
it jeopardizes the efforts to ...
Predicting major depressive disorder among adults Living with HIV In Uganda: An Artificial Intelligence Approach
(Makerere University, 2022-08-01)
Background
Major depressive disorder is a leading cause of disability worldwide and a major contributor
to the overall global burden of disease. The biggest percentage of the MDD burden pertains to
low- and middle-income ...
CDd4 t- cell immune responses in haart-treated hiv-infected adults who attain normal CD4 counts in a Ugandan cohort
(Makerere University, 2014-05)
Background: Majority of HIV-infected individuals who start HAART at CD4 counts <200 cells/µl show a marked CD4+T-cell increase to absolute CD4 counts above 500 cells/µl. The CD4+ T-cell count is the main measure for immune ...
PREVALENCE OF VIROLOGICAL SUPPRESSION AND PATTERNS OF ACQUIRED HIV DRUG RESISTANCE AMONG INDIVIDUALS ON FIRST-LINE ANTIRETROVIRAL THERAPY IN FISHERFOLK COMMUNITIES IN UGANDA
(2018-10-03)
Background: The UNAIDS targets sustained viral suppression among at least 90% of HIV individuals on antiretroviral therapy (ART), yet viral load (VL) monitoring is rarely done in resource-limited settings due to high costs. ...
Long term non-progressor-derived CD4+ T Cell In-Vitro susceptibility to HIV-1 infection
(Makerere University, 2018-09-01)
Introduction: World over, there are antiretroviral therapy naïve individuals infected with HIV who maintain their CD4+T cell count above 500 cells/μl over 7-10 years (termed as Long Term Non-progressors, LTNP). A subset ...
Evaluation of the impact of HIV-1 infections on Cytomegalovirus Specific T cells responses
(Makerere University, 2019-10-30)
Background: Incomplete understanding of the effect of HIV-1 infection on T cell immune response to HCMV is a barrier to development of better control strategies for HCMV infection in HIV-1 infected individuals. Depletion ...
Development and validation of an HPLC-UV method for the simultaneous determination of Efavirenz and Dolutegravir in human plasma
(Makerere University, 2022-12)
Background: Although HIV/AIDS possess a challenge, global efforts have been mounted to address the epidemic. These include the massive role out of anti-retroviral therapy (ART) globally. To date either efavirenz or ...
Correlation of plasma HIV-1 p24 antigen levels with viral load in samples of HIV positive patients on ART in Uganda
(Makerere University, 2022-12)
Globally, a total of 38.0 million people living with HIV, of which 1.7 million people became newly infected with HIV in 2019. Additionally, an average of 690,000 people died from AIDS-related illnesses in 2019, and 26 ...
Inflammaging and anti-inflammaging cytokines in the HIV-seropositive geriatric population in Uganda
(Makerere University, 2023)
Background: Although the life expectancy of people living with HIV (PLWH) has increased significantly, HIV infection seems to be associated with accelerated ageing processes compared to uninfected individuals. Longevity ...
Binding characteristics of selected commercial antibodies against recombinant HIV Subtype D P24 antigens
(Makerere University, 2023-01)
The standard method for monitoring HIV treatment response is quantitative RT-PCR, but it is difficult to implement in low and middle income countries due to infrastructure and personnel requirements. Point of care technologies ...