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Now showing items 11-20 of 24
Viral load and reverse transcriptase drug resistance mutations in HIV-1 isolated from mothers who transmit the virus to their infants at Kibagabaga Hospital PMTCT Clinic, Kigali, Rwanda
(Makerere University, 2014-09)
Mother to Child Transmission (MTCT) of HIV is the largest source of HIV infection in children below the age of 15 years, affecting five-million infants per year. HIV/AIDS is a disease with known modes of transmission and ...
Relationship between phenotypic features of Cryptococcus Neoformans and CSF opening pressure in HIV–infected patients with cryptococcal meningitis in Mulago Hospital, Kampala, Uganda.
(Makerere University, 2012-05)
Background: Cryptococcal meningoencephalitis(CM) is a highly prevalent HIV associated opportunistic infection in Africa, with mortality attributable to raised intracranial pressure (ICP) as high as 50%, rising to 100% among ...
Combined antiretroviral treatment modification among HIV infected patients in New Nyanza Provincial General Hospital, Western Kenya
(2012-06)
Background
Limited combined antiretroviral therapy (cART) regimens in resource constrained settings call for the need to optimize the available options in order to improve the durability of potent and well-tolerated first ...
Tenofovir related renal toxicity monitoring in antiretroviral therapy (ART) accredited sites: A situational analysis for Uganda
(Makerere University, 2014-09)
Background: In Uganda, Tenofovir-based regimen is recommended as first line particularly for HIV/AIDS adult and adolescent patient and for option B+ in prevention of mother-to-child transmission (PMTCT). As a result of ...
Growth patterns and survivability of the different mycobacterium tuberculosis sub lineages predominant in peri urban Kampala
(Makerere University, 2014-05)
Background: Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB) infects over 2 billion people world-wide with the vast majority of deaths from TB in the developing world. Strains of MTB vary in ...
Whole exome sequencing uncovers genetic predisposition to pediatric HIV disease progression and hyperhemolysis syndrome
(Makerere University, 2022-07)
Background: Populations of African ancestry hold a disproportionate burden of infectious and non-infectious diseases. Genetic variants, with population allele frequencies ranging from rare to common variants, are believed ...
Low-abundance drug resistant variant patterns among HIV-1 patients with virological failure in Uganda
(Makerere University, 2022-03)
Background: The emergence and spread of antiretroviral drug resistant HIV-1 variants is one
of the major factors responsible for therapeutic failure in persons living with HIV (PLWH) as
it jeopardizes the efforts to ...
Effect of hydrocortisone hormone on in-vitro reactivation of HIV-1 reservoirs
(Makerere University, 2022-07)
The persistence of the HIV-1 reservoir in infected individuals represents a major hurdle to the development of a cure and complete eradication of HIV-1 infection. Stress hormones have also been shown to modulate immune ...
HIV-1 co-receptor usage of contemporary transmitted/ founder viruses in Uganda
(Makerere University, 2022-12-21)
Background: Globally, HIV remains a global public health threat despite the serious efforts to stop it using combination antiretroviral therapy. This could be attributed to the lack of preventative and curative treatment ...
Patient single nucleotide polymorphisms assiocated with Mycobacterium tuberculosis genotypes in Ugandan population
(Makerere University, 2022-12)
Uganda is one of the 30 World Health Organization-designated countries with a high burden of TB/HIV, with three main dominant genotypes that cause tuberculosis. Recent studies have shown that the M. tuberculosis Uganda ...