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Simulation of clonal expansion and latent HIV reservoir size prediction using machine learning in virally suppressed individuals in Uganda
(Makerere University, 2022-07)
Background: HIV can survive as pro-viruses that do not undergo transcription mostly within resting memory CD4+ T cells despite prolonged antiretroviral therapy (ART). This Latent Viral Reservoir (LVR) has an extremely long ...
Whole exome sequencing uncovers genetic predisposition to pediatric HIV disease progression and hyperhemolysis syndrome
(Makerere University, 2022-07)
Background: Populations of African ancestry hold a disproportionate burden of infectious and non-infectious diseases. Genetic variants, with population allele frequencies ranging from rare to common variants, are believed ...
Low-abundance drug resistant variant patterns among HIV-1 patients with virological failure in Uganda
(Makerere University, 2022-03)
Background: The emergence and spread of antiretroviral drug resistant HIV-1 variants is one
of the major factors responsible for therapeutic failure in persons living with HIV (PLWH) as
it jeopardizes the efforts to ...
Effect of hydrocortisone hormone on in-vitro reactivation of HIV-1 reservoirs
(Makerere University, 2022-07)
The persistence of the HIV-1 reservoir in infected individuals represents a major hurdle to the development of a cure and complete eradication of HIV-1 infection. Stress hormones have also been shown to modulate immune ...
Metabolic syndrome among HIV positive patients on antiretroviral therapy attending the art clinic at Fortportal Regional Referral Hospital
(2022-10-18)
ABSTRACT
Introduction
The continuing evolution of potent antiretroviral therapy (ART) has resulted in dramatic reductions in HIV-associated morbidity and mortality. However, the availability of newer ART regimes has ...
Correlation of plasma HIV-1 p24 antigen levels with viral load in samples of HIV positive patients on ART in Uganda
(Makerere University, 2022-12)
Globally, a total of 38.0 million people living with HIV, of which 1.7 million people became newly infected with HIV in 2019. Additionally, an average of 690,000 people died from AIDS-related illnesses in 2019, and 26 ...