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Characterisation of Resistance Associated Variants (RAVs) to the newly approved anti-tuberculosis drugs Delamanid, Pretomanid, Bedaquiline, Clofazimine and Linezolid in isolates from a 2016/2017 Tanzanian Anti-Tuberculosis Drug Resistance Survey
(Makerere University, 2022)
Background: Drug-resistant Tuberculosis (TB) undermines the effort to curb TB disease. It is associated with higher treatment costs, longer treatment periods and more adverse effects (Jeon, 2015). Recently, three new ...
Prevalence of Antimalarial self- medication and artemisinin genotypic resistance in plasmodium falciparum parasites isolated from malaria symptomatic patients attending Dokolo Health Centre
(Makerere University, 2022-09-14)
Background: Malaria remains the major cause of death in sub-Saharan Africa. Interventions like use of insecticide treated mosquito nets (ITNs), IRS, antimalarial drugs have been used to combat malaria in Uganda with minimal ...
Magnitude of bilateral cataracts and factors associated with delayed uptake of cataract surgery among adult patients with operable cataract seen at Mulago Hospital.
(Makerere University, 2022-01-20)
Background. Cataract is an opacity in the natural lens of the eye that causes visual impairment to vision of less than 6/9. Cataract causes 51% of global blindness and any delay in timely uptake of cataract surgery results ...
The evaluation of effect of canarium schweinfurthii leaf and pulp extracts on blood glucose levels in oral glucose load - induced hyperglycemia, heamatological parameters and safety in wistar albino rats
(Makerere University, 2022-03-14)
Background: Canarium schweinfurthii (C. schweinfurthii) is a common medicinal plant in Uganda used as food and as medicine in the management of Diabetes mellitus type 2 and anemia by local communities and traditional ...
Vegf protein expression in gastric cancer and associated clinical pathological features as seen at the Department of Pathology, Makerere University
(Makerere University, 2022-03-17)
Background: Gastric cancer is the 5th most common cancer accounting for 5.7% of all cancers in the world and causes about 783,000 deaths annually. In Uganda the incidence of gastric cancer increased from 0.8 cases per ...
Attitudes and practices of herbalists towards the informed consent process
(Makerere University, 2022)
Introduction: Informed Consent (IC) is a major cornerstone in medical ethics that is expected to be implemented universally in healthcare. The growing use of herbal medicines in developing countries has aroused concerns, ...
Evaluation of contractile activity of the extracts of Gynandropsis gynandra Linn on isolated rabbit uterus and ileum
(Makerere University, 2022)
Diarrhea due to exaggerated GIT motility and maternal death due to delayed labor remain serious health challenges; and among the leading causes of mortality globally especially among children and pregnant mothers respectively. ...
Prevalence and histological types of kidney disease in autopsied persons at Kampala Capital City Authority Mortuary.
(Makerere University, 2022-02)
Introduction: It is estimated globally that in 2016, 5-10 million people died from kidney dis-ease (KD) and about 1.7 million died from acute kidney injury. In sub Saharan Africa the prevalence of KD is quite high and is ...
Simulation of clonal expansion and latent HIV reservoir size prediction using machine learning in virally suppressed individuals in Uganda
(Makerere University, 2022-07)
Background: HIV can survive as pro-viruses that do not undergo transcription mostly within resting memory CD4+ T cells despite prolonged antiretroviral therapy (ART). This Latent Viral Reservoir (LVR) has an extremely long ...
Unravelling the genetic risk associated with major depressive disorder among an ethnically diverse African ancestry population
(Makerere University, 2022-03)
Major depressive disorder (MDD), which is a significant contributor to the global health burden is characterised by a pervasive low mood and an inability to feel pleasure in normally pleasurable activities. Most MDD genetic ...