Now showing items 1-6 of 6
Significance of minority HIV-1 X-4-tropic variants, Host CCR5 promoter genotype in predicting paediatric Virological failure
(Makerere University, 2019-11-04)
Background By Sept 2018, only 59.3% of all HIV positive children on cART under 5 years were achieving virological suppression compared to 88.4% in the general population in Uganda. However, while its known that a tropism ...
Molecular Diversity of HIV-1 among Long Term Non-progressors attending MJAP-ISS clinic, Mulago
(Makerere University, 2018-11)
Background: To date efforts are still being made to develop an efficacious and safe vaccine to stop the spread of Human Immunodeficiency Virus. Long term non-progressors (LTNPs); who harbour the virus but clinically show ...
Evaluation of the effect of pim6 on the induction of hiv-1 expression from memory cd4+ t cells of virally suppressed hiv-1 patients attending TASO clinic, Mulago.
(Nakimuli Cynthia, 2020-01-07)
Background: Latent HIV-1 reservoirs harbour human immunodeficiency virus type 1 (HIV-1) proviral DNA which can be reactivated to express viral RNA. Memory CD4+ T cells in HIV-infected persons are critical as HIV reservoirs, ...
A molecular phylogenetic and modeling approach towards understanding the transmission dynamics and genetic diversity of HIV-1 in the fishing communities of Lake Victoriaa, Uganda
(Makerere University, 2019-11-29)
Fishing communities (FCs) in Uganda have a greater HIV burden relative to other high-risk groups and the general population (GP). As a result of the very high HIV-1 incidence rates, they have been hypothesized to act ...
Interferon Sensitivity Profiles of HIV-1 Transmitter Founder Viruses of Subtypes A, D and AD Recombinants in Uganda.
(Makerere University, 2021-02-08)
ABSTRACT Background: In 80–90% of HIV-1 discordant partners, infection of the naive partner always results from the successful transmission and propagation of a single virus variant, termed the Transmitter Founder (TF) ...
T- cell activation and senescence phenotypes among people living with hiv-1 with advanced immunosuppression
(Makerere University, 2021-04-29)
INTRODUCTION. T cell activation and senescence phenotype markers among HIV-1 infected patients with advanced immunosuppression are key components in the immunopathogenesis of HIV. In HIV infection, senescence is accelerated ...