Browsing School of Bio-Medical Sciences (Bio-Medical) by Author "Aklillu, Eleni"
-
Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans
Mukonzo, Jackson K; Waako, Paul; Ogwal-Okeng, Jasper; Gustafsson, Lars L.; Aklillu, Eleni (Lippincott Wilkins & Williams, 2010)Abstract: Quinine is one of the most effective antimalarial drugs, although its clinical use is limited as a result of its narrow safety margin. Quinine is a substrate of the polymorphic p-glycoprotein and CYP3A4/3A5. This ... -
HIV/AIDS patients display lower relative bioavailability of Efavirenz than healthy subjects
Mukonzo, Jackson K; Nanzigu, Sara; Rekic, Dinko; Waako, Paul; Roshammar, Daniel; Ashton, Michael; Ogwal-Okeng, Jasper; Gustafsson, Lars L.; Aklillu, Eleni (Adis Data Information BV., 2011)Background: Pharmacokinetic studies of antiretroviral drugs are often conducted in adult healthy subjects, and the results are extrapolated to HIV/AIDS patients. HIV/AIDS, however, is known to cause morphological and ... -
A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans
Mukonzo, Jackson; Röshammar, Daniel; Waako, Paul; Andersson, Maria; Fukasawa, Takashi; Milani, Lili; Svensson, Jan Olof; Ogwal-Okeng, Jasper; Gustafsson, Lars L.; Aklillu, Eleni (Wiley-Blackwell, 2009)AIMS Efavirenz exhibits pharmacokinetic variability causing varied clinical response. The aim was to develop an integrated population pharmacokinetic/pharmacogenetic model and investigate the impact of genetic variations, ... -
A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans
Mukonzo, Jackson K; Röshammar, Daniel; Waako, Paul; Andersson, Maria; Fukasawa, Takashi; Milani, Lili; Svensson, Jan Olof; Ogwal-Okeng, Jasper; Gustafsson, Lars L.; Aklillu, Eleni (The British Pharmacological Society, 2009)AIMS Efavirenz exhibits pharmacokinetic variability causing varied clinical response. The aim was to develop an integrated population pharmacokinetic/pharmacogenetic model and investigate the impact of genetic variations, ...