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dc.contributor.authorMoore, Christopher C
dc.contributor.authorJacob, Shevin T
dc.contributor.authorPinkerton, Relana
dc.contributor.authorBanura, Patrick
dc.contributor.authorMeya, David B
dc.contributor.authorReynolds, Steven J
dc.contributor.authorKenya-Mugisha, Nathan
dc.contributor.authorMayanja-Kizza, Harriet
dc.contributor.authorScheld, Michael. W
dc.date.accessioned2012-01-31T10:21:55Z
dc.date.available2012-01-31T10:21:55Z
dc.date.issued2009
dc.identifier.citationMore, C.C., Jacob, S.T., Pinkerton, R., Banura, P., Meya, D.B., Reynolds, S.J., Kenya-Mugisha, N., Mayanja-Kizza, H., Scheld, M.W. (2009). Treatment of severe sepsis with Artemether-Lumefantrine Is associated with decreased mortality in Ugandan patients without malaria. American Journal of Tropical Medicine and Hygiene, 80(5)en_US
dc.identifier.issn0002-9637
dc.identifier.urihttp://hdl.handle.net/10570/366
dc.description.abstractWe enrolled 382 patients at two hospitals in Uganda in a prospective observational study of severe sepsis. Because artemisinins improve survival in murine sepsis models, we performed a post hoc analysis of the association between the use of artemether-lumefantrine (A-L) and mortality in patients with or without malaria. In patients with negative malaria smears ( N = 328 of 379), Kaplan–Meier curves revealed decreased combined inpatient and 30-day mortality among patients receiving A-L versus those who did not (20.6%, SE = 10.6 versus 48.8%, SE = 3.2; Log rank χ2 = 3.93, P = 0.048). The decrease in mortality associated with A-L was maintained in the most clinically ill patients determined by Karnofsky Performance Scores ≤ 50 (16.7%, SE = 15.2 versus 58.3%, SE = 3.7; Log rank χ2 3.94, P = 0.041). Research into the properties of A-L is needed to improve treatment of sepsis without compromising malarial susceptibility.en_US
dc.language.isoenen_US
dc.publisherAmerican Society of Tropical Medicine and Hygieneen_US
dc.subjectMalariaen_US
dc.subjectArtemether-Lumefantrineen_US
dc.subjectAntimalarial treatmenten_US
dc.subjectMortalityen_US
dc.subjectMycobacteria tuberculosisen_US
dc.subjectCD4 lymphocyte counten_US
dc.subjectHIV/AIDSen_US
dc.titleTreatment of severe sepsis with Artemether-Lumefantrine Is associated with decreased mortality in Ugandan patients without malariaen_US
dc.typeJournal article, peer revieweden_US


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