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dc.contributor.authorBuwembo, William
dc.contributor.authorMugisha Rwenyonyi, Charles
dc.contributor.authorSwedberg, Gote
dc.contributor.authorKironde, Fred
dc.date.accessioned2014-03-13T11:46:37Z
dc.date.available2014-03-13T11:46:37Z
dc.date.issued2012
dc.identifier.citationBuwembo, W., Mugisha R. C., Swedberg, G., & Kironde, F. (2012). Cotrimoxazole Prophylaxis specifically selects for Cotrimoxazole resistance in Streptococcus mutans and Streptococcus sobrinus with varied Polymorphisms in the target genes folA and folP, International Journal of Microbiology, 2012: 1-10.en_US
dc.identifier.otherdoi:10.1155/2012/916129
dc.identifier.urihttp://hdl.handle.net/10570/2391
dc.description.abstractThe selection of antibiotic resistance by cotrimoxazole prophylaxis was evaluated, and we characterized the mechanism of cotrimoxazole resistance in Streptococcus mutans and Streptococcus sobrinus. In vitro susceptibility to six antibiotics was evaluated on 64 mutans streptococci group (MSG) isolates from a cotrimoxazole prophylaxis group and compared to 84 MSG isolates from a nonprophylaxis group. The folA and folP genes were sequenced and compared with reference sequences at NCBI. Only resistance to cotrimoxazole was significantly higher in the prophylaxis group (54.7% versus 15.5%, OR = 6.59, 95% CI: 2.89–15.3,P < 0.05). Resistance to amoxicillin, ceftriaxone, chloramphenicol, erythromycin, and tetracycline was 1.4%, 25.5%, 6.2%, 6.5%, and 29.6% of the isolates, respectively. Considerable polymorphisms were found in the folP gene in S. mutans, but this could not be linked to sulfonamide drug resistance. No variation was seen in folP or folA genes of S. sobrinus. Genetic transfer of folate pathway genes seems unlikely in these isolates.en_US
dc.description.sponsorshipSwedish Agency for Research Cooperationen_US
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporation, International Journal of Microbiologyen_US
dc.subjectCotrimoxazole Prophylaxisen_US
dc.subjectStreptococcus mutansen_US
dc.subjectStreptococcus sobrinusen_US
dc.subjectPolymorphismsen_US
dc.subjectGenesen_US
dc.subjectfolAen_US
dc.subjectfolPen_US
dc.titleCotrimoxazole Prophylaxis specifically selects for Cotrimoxazole resistance in Streptococcus mutans and Streptococcus sobrinus with varied Polymorphisms in the target genes folA and folPen_US
dc.typeArticleen_US


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