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Test and treat policy: Effect on ART initiation and retention and health system barriers and facilitators to implementation in AHF Uganda Cares Clinics in Central Uganda
(Makerere University, 2022-05)
Background: The ‘Test and Treat’ policy was introduced by the WHO in 2015 as a measure to extend the benefits of ART to all HIV positive patients and, in a bid to enable the achievement of the UNAIDS 95-95-95 2030 ...
Incidence and factors associated with late sputum culture conversion among multi-drug resistant tuberculosis patients on treatment at Mulago Hospital
(Makerere University, 2021-03-25)
Introduction: Tuberculosis (TB) remains one of the most common causes of death from an infectious disease. Late sputum culture conversion of Multi-Drug Resistant Tuberculosis (MDR-TB) patients poses a risk for poor treatment ...
Prevalence, immunological profile, and factors associated with latent tuberculosis infection among adults with diabetes mellitus at Kiruddu National Referral Hospital
(Makerere University, 2022-10)
Introduction: The dual epidemic of Diabetes Mellitus (DM) and tuberculosis (TB) is a growing public health challenge in Sub-Saharan Africa (SSA), Uganda inclusive. Due to the immunologic dysfunction associated with diabetes ...
In vitro activity of mycobacteriophages against Mycobacterium tuberculosis biofilms
(Makerere University, 2021-03)
Tolerance of Mycobacterium tuberculosis to antibiotics has been associated with its tendency to grow in cell aggregates known as biofilms. These biofilms consist of layers of cells covered by a lipid-rich extracellular ...
Prevalence of chronic obstructive pulmonary disease and associated factors among HIV infected patients attending the Mulago ISS Clinic
(Makerere University, 2017-10-12)
Background: Chronic obstructive pulmonary disease (COPD) will be the 3rd leading cause of death worldwide by 2020. Data from Africa indicate that the prevalence of COPD is high (4% to 25%). We sought to determine its ...
Prevalence and factors associated with depressive illness in patients with tuberculosis in Mulago Hospital
Background: Depression is a major cause of the global disease burden and globally affects 350-400 million persons making it the largest contributor to years lived with disability. Among patients with chronic physical ...
Prevalence and factors associated with pulmonary tuberculosis among children aged 2 to 59 months presenting with severe pneumonia at Alsabah Children’s Hospital, Juba, South Sudan
(Makerere University, 2019-09)
Background: Tuberculosis (TB) is a major public health problem at a global level. According to the World Health Organization (WHO) in 2018, approximately 10 million people developed TB in 2017, of which 1.0 million (10%) ...
Strain diversity of mycobacterium tuberculosis non-Uganda isolates from patients with pulmonary tuberculosis in Kawempe
(Makerere University, 2013-05)
Background: Tuberculosis is a major public health problem in peri-urban areas of Kampala and Uganda in general. To date there is inconclusive information about strain diversity of Mycobacterium tuberculosis of the non ...
Suspected adverse drug reactions of isoniazid preventive therapy in HIV-positive patients at three regional hospitals: prevalence, associated factors, management and reporting
(Makerere University, 2021-11)
Background
Tuberculosis (TB) is the 10th leading cause of death globally and the leading cause of death from a single infectious agent among people living with HIV (PLHIV). Uganda is among the 30 high burden TB countries ...
Compensatory mutations in rpoA, rpoC and rpoD genes among rifampicin-resistant Mycobacterium tuberculosis isolates from Uganda
(Makerere University, 2019-11-11)
Background; Mycobacterium tuberculosis can acquire resistance to rifampicin through mutations in the rpoB gene. This is normally accompanied by the fitness cost which however can be mitigated by the acquired secondary ...