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Burden of tuberculosis in Kampala, Uganda
(World Health Organization (WHO), 2008)
Objective: To determine the prevalence and incidence of tuberculosis in one of Uganda’s poor peri-urban areas. Methods: Multi-stage sampling was used to select a sample of households whose members were evaluated for presence ...
A metabolic biosignature of early response to anti-tuberculosis treatment
(BMC Infectious Diseases, 2014)
Background: The successful treatment of tuberculosis (TB) requires long-term multidrug chemotherapy. Clinical trials to evaluate new drugs and regimens for TB treatment are protracted due to the slow clearance of Mycobacterium ...
Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings
(Elsevier, 2008-08)
The immune reconstitution inflammatory syndrome (IRIS) has emerged as an important early complication of antiretroviral therapy (ART) in resource-limited settings, especially in patients with tuberculosis. However, there ...
Predictors of treatment failure among patients with smear positive pulmonary tuberculosis in the tuberculosis clinic in Mulago Hospital: a case control study
(2008)
Background: Treatment failure is a threat to the control of tuberculosis (TB) because of its association with Multi Drug Resistant tuberculosis (MDR TB) and also because affected patients continue to spread TB. Patients ...
Incidence and predictors of mortality and the effect of tuberculosis immune reconstitution inflammatory syndrome in a cohort of TB/HIV patients commencing antiretroviral therapy
(Lippincott Wilkins & Williams, 2011)
Background: Tuberculosis-HIV (TB-HIV) coinfection remains an
important cause of mortality in antiretroviral therapy (ART)
programs. In a cohort of TB-HIV–coinfected patients starting
ART, we examined the incidence and ...
The TB pandemic: an old problem seeking new solutions
(Blackwell, 2007)
Meya DB, McAdam KPWJ (Infectious Disease Institute, Kampala, Uganda). The TB pandemic: an old problem seeking new solutions (Review). J Intern Med 2007; 261: 309–329. Tuberculosis (TB) continues to kill more than 2 million ...
Tuberculosis immune reconstitution inflammatory syndrome in countries with limited resources
(International Union Against Tuberculosis and Lung Disease, 2006)
Mycobacterium tuberculosis infection accounts for probably one third of human immunodeficiency virus (HIV)related immune reconstitution inflammatory syndrome (IRIS) events, particularly in developing countries where HIV ...
Elucidating emergence and transmission of multidrug-resistant tuberculosis in treatment experienced patients by whole genome sequencing
(PLOS One, 2013)
Background: Understanding the emergence and spread of multidrug-resistant tuberculosis (MDR-TB) is crucial for its control. MDR-TB in previously treated patients is generally attributed to the selection of drug resistant ...
The TB pandemic: an old problem seeking new solutions
(Blackwell, 2007)
Tuberculosis (TB) continues to kill more than 2 million people globally each year. Annual TB case notification rates have risen up to fourfold since the mid-1980s, with the highest rate of 1000/100 000 around Cape Town, ...
Tuberculosis immune reconstitution inflammatory syndrome in countries with limited resources
(International Union Against Tuberculosis and Lung Disease, 2006)
Mycobacterium tuberculosis infection accounts for probably one third of human immunodeficiency virus (HIV)related immune reconstitution inflammatory syndrome (IRIS) events, particularly in developing countries where HIV ...