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Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial
(BioMed Central, 2009-10-24)
Background: Malaria carries high case fatality among children with sickle cell anaemia. In Uganda, chloroquine is used for prophylaxis in these children despite unacceptably high levels of resistance. Intermittent presumptive ...
Complexity of plasmodium falciparum clinical samples from Uganda during short-term culture.
(University of Chicago Press, 2008-08-22)
We cultured Plasmodium falciparum parasites from 98 Ugandan children with malaria and determined the complexity of infection (COI) on the basis of msp-2 polymorphisms daily for 9 days. The mean COI decreased during culture ...
Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda.
(Oxford University Press, 2009-11-04)
Background. Amodiaquine (AQ) is paired with artesunate (AS) or sulfadoxine-pyrimethamine (SP) in recommended antimalarial regimens. It is unclear how readily AQ resistance will be selected with combination chemotherapy. ...
Variations of plasma concentrations of artemether-lumefantrine with age and weight in children presenting with uncomplicated malaria at Mulago Hospital.
(2009-10)
INTRODUCTION:
Malaria is still one of the main causes of mortality and morbidity in Ugandan children with the under 5 year mortality rate of 136/100,000. ACTs are the first line of treatment of uncomplicated malaria. ...
Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial.
(2007-05-18)
Objectives: To compare the efficacy and safety of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) for treating uncomplicated falciparum malaria in Uganda. Design: Randomized single-blinded clinical ...