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Clinical spectrum, risk factors and outcome of immune reconstitution inflammatory syndrome in patients with tuberculosis-HIV coinfection
(International Medical Press, 2012)
BACKGROUND:
Here, we aimed to determine the clinical spectrum, predictors and outcomes of paradoxical tuberculosis-immune reconstitution inflammatory syndrome (TB-IRIS) in a resource-limited setting.
METHODS:
In a ...
Bronchoalveolar lavage enzyme-linked immunospot for diagnosis of smear-negative tuberculosis in HIV infected patients
(Public Library of Science, 2012-06-26)
Background: Peripheral blood interferon-gamma release assays (IGRAs) have sub-optimal sensitivity and specificity for diagnosis of active pulmonary tuberculosis (TB). However, assessment of local immune responses has been ...
In reply to `Empirical tuberculosis treatment or improved diagnostics?'
(International Union Against Tuberculosis and Lung Disease, 2012-02-16)
We read the article by Lawn and colleagues with great interest. Atypical presentation and limited diagnostic capability in resource-limited settings lead to delays in treatment that could contribute to high rates of ...