Browsing College of Health Sciences (CHS) by Author "Staedke, Sarah G."
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The age-specific incidence of hospitalized paediatric malaria in Uganda
Mpimbaza, Arthur; Walemwa, Richard; Kapisi, James; Sserwanga, Asadu; Namuganga, Jane Frances; Kisambira, Yasin; Tagoola, Abner; Nanteza, Jane Frances; Rutazaana, Damain; Staedke, Sarah G.; Dorsey, Grant; Opigo, Jimmy; Kamau, Alice; Snow, Robert W. (BMC, 2020)Background: Understanding the relationship between malaria infection risk and disease outcomes represents a fundamental component of morbidity and mortality burden estimations. Contemporary data on severe malaria risks ... -
Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda
Yeka, Adoke; Kamya, Moses R.; Dorsey, Grant; Talisuna, Ambrose; Lugemwa, Myers; Rwakimari, John Bosco; Staedke, Sarah G.; Rosenthal, Philip J.; Wabwire-Mangen, Fred; Bukirwa, Hasifa (Public Library of Science, 2008-06)Background: Uganda recently adopted artemether-lumefantrine (AL) as the recommended first-line treatment for uncomplicated malaria. However, AL has several limitations, including a twice-daily dosing regimen, recommendation ... -
Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial.
Kamya, Moses.R; Yeka, Adoke; Bukirwa, Hasifa; Lugemwa, Myers; Rwakimari, John B.; Staedke, Sarah G.; Talisuna, Ambrose O.; Greenhouse, Bryan; Nosten, Francois; Rosenthal, Philip J.; Wabwire-Mangen, Fred; Dorsey, Grant (2007-05-18)Objectives: To compare the efficacy and safety of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) for treating uncomplicated falciparum malaria in Uganda. Design: Randomized single-blinded clinical ... -
Artemisinin Combination Therapies for Treatment of Uncomplicated Malaria in Uganda
Bukirwa, Hasifa; Talisuna, Ambrose; Yeka, Adoke; Kamya, Moses R; Talisuna, Ambrose O.; Banek, Kristin; Bakyaita, Nathan; Rwakimari, John Bosco; Rosenthal, Philip J.; Wabwire-Mangen, Fred; Dorsey, Grant; Staedke, Sarah G. (Public Library of Science, 2006-05)Objectives: To compare the efficacy and safety of artemisinin combination therapies for the treatment of uncomplicated falciparum malaria in Uganda. Design: Randomized single-blind controlled trial. Setting: Tororo, Uganda, ... -
Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda
Banek, Kristin; Yeka, Adoke; Bakyaita, Nathan; Staedke, Sarah G.; Talisuna, Ambrose; Kironde, Fred; Kamya, Moses.R; Nsobya, Samuel L.; Kilian, Albert; Slater, Madeline; Dorsey, Grant; Wabwire-Mangen, Fred; Rosenthal, Philip J.; Reingold, Arthur (Public Library of Science, 2005-07)Background Drug resistance in Plasmodium falciparum poses a major threat to malaria control. Combination antimalarial therapy including artemisinins has been advocated recently to improve efficacy and limit the spread of ... -
Challenges and opportunities for use of long‑lasting insecticidal nets to prevent malaria during overnight travel in Uganda: a qualitative study
Ekusai‑Sebatta, Deborah; Arinaitwe, Emmanuel; Mpimbaza, Arthur; Nankabirwa, Joaniter I.; Drakeley, Chris; Rosenthal, Philip J.; Staedke, Sarah G.; Muyinda, Herbert (BioMed Central, 2021)Background: Travel is a well‑recognized risk factor for malaria. Within sub‑Saharan Africa, travelers from areas of lower to higher transmission intensity are potentially at high risk of malaria. Long‑lasting insecticidal ... -
Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic Falciparum Malaria Infections in Uganda
Tukwasibwe, Stephen; Mugenyi, Levi; Mbogo, George W.; Nankoberanyi, Sheila; Maiteki-Sebuguzi, Catherine; Joloba, Moses L.; Nsobya, Samuel L.; Staedke, Sarah G.; Rosenthal, Philip J. (Journal of Infectious Diseases, 2014)We explored associations between Plasmodium falciparum drug resistance–mediating polymorphisms and clinical presentations in parasitemic children enrolled in a cross-sectional survey in Tororo, Uganda, using a retrospective ... -
Malaria diagnosed in an urban setting strongly associated with recent overnight travel: A case–control study from Kampala, Uganda
Arinaitwe, Emmanuel; Mpimbaza, Arthur; Nankabirwa, Joaniter I.; Kamya, Victor; Asiimwe, Alan; Kuule, Julius K.; Kamya, Moses R.; Drakeley, Chris; Dorsey, Grant; Rosenthal, Philip J.; Staedke, Sarah G. (2020)Malaria is frequently diagnosed in urban Kampala, despite low transmission intensity. To evaluate the association between recent travel out of Kampala and malaria, we conducted a matched case–control study. Cases were ... -
Practical implications of a relationship between health management information system and community cohort–based malaria incidence rates
Kigozi, Simon P.; Giorgi, Emanuele; Mpimbaza, Arthur; Kigozi, Ruth N.; Bousema, Teun; Arinaitwe, Emmanuel; Nankabirwa, Joaniter I.; Sebuguzi, Catherine M.; Kamya, Moses R.; Staedke, Sarah G.; Dorsey, Grant; Pullan, Rachel L. (2020)Global malaria burden is reducing with effective control interventions, and surveillance is vital to maintain progress. Health management information system (HMIS) data provide a powerful surveillance tool; however, its ... -
A quasi-experimental study estimating the impact of long-lasting insecticidal nets with and without piperonyl butoxide on pregnancy outcomes
Roh, Michelle E.; Oundo, Brenda; Dorsey, Grant; Shiboski, Stephen; Gosling, Roly; Glymour, M. Maria; Staedke, Sarah G.; Bennett, Adam; Sturrock, Hugh; Mpimbaza, Arthur (BMC, 2022)Background: Long-lasting insecticidal nets (LLINs) are the main vector control tool for pregnant women, but their efficacy may be compromised, in part, due to pyrethroid resistance. In 2017, the Ugandan Ministry of Health ... -
Rapid shifts in the age‑specific burden of malaria following successful control interventions in four regions of Uganda
Kigozi, Simon P.; Kigozi, Ruth N.; Epstein, Adrienne; Mpimbaza, Arthur; Sserwanga, Asadu; Yeka, Adoke; Nankabirwa, Joaniter I.; Halliday, Katherine; Pullan, Rachel L.; Rutazaana, Damian; Sebuguzi, Catherine M.; Opigo, Jimmy; Kamya, Moses R.; Staedke, Sarah G.; Dorsey, Grant; Greenhouse, Bryan; Rodriguez‑Barraquer, Isabel (BMC, 2020)Background: Malaria control using long-lasting insecticidal nets (LLINs) and indoor residual spraying of insecticide (IRS) has been associated with reduced transmission throughout Africa. However, the impact of transmission ... -
Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda
Bakyaita, Nathan; Dorsey, Grant; Adoke, Yeka; Banek, Kristin; Staedke, Sarah G.; Kamya, Moses R.; Talisuna, Ambrose; Kironde, Fred; Nsobya, Sam; Kilian, Albert; Reingold, Arthur; Rosenthal, Philip J.; Wabwire-Mangen, Fred (2005)The use of combinations of inexpensive drugs for the treatment of malaria in Africa has been proposed as an interim policy while awaiting the widespread availability of more effective regimens. We compared sulfadoxinepyrimethamine ...