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A metabolic biosignature of early response to anti-tuberculosis treatment
(BMC Infectious Diseases, 2014)
Background: The successful treatment of tuberculosis (TB) requires long-term multidrug chemotherapy. Clinical trials to evaluate new drugs and regimens for TB treatment are protracted due to the slow clearance of Mycobacterium ...
Evaluation of capilia TB assay for rapid identification of mycobacterium tuberculosis complex in BACTEC MGIT 960 and BACTEC 9120 blood cultures
(BioMed Central, 2012)
Background: Capilia TB is a simple immunochromatographic assay based on the detection of MPB64 antigen specifically secreted by the Mycobacterium tuberculosis complex (MTC). Capilia TB was evaluated for rapid identification ...
Augmentation of Apoptosis and Interferon-g Production at sites of active Mycobacterium Tuberculosis infection in Human Tuberculosis
(University of Chicago Press, 2001-02-08)
Pleural tuberculosis (TB) was employed as a model to study T cell apoptosis at sites of active Mycobacterium tuberculosis (MTB) infection in human immunodeficiency virus (HIV)–coinfected (HIV/TB) patients and patients ...
Growth patterns and survivability of the different mycobacterium tuberculosis sub lineages predominant in peri urban Kampala
(Makerere University, 2014-05)
Background: Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB) infects over 2 billion people world-wide with the vast majority of deaths from TB in the developing world. Strains of MTB vary in ...
Strain diversity of mycobacterium tuberculosis non-Uganda isolates from patients with pulmonary tuberculosis in Kawempe
(Makerere University, 2013-05)
Background: Tuberculosis is a major public health problem in peri-urban areas of Kampala and Uganda in general. To date there is inconclusive information about strain diversity of Mycobacterium tuberculosis of the non ...
Insights into genomic variations between Mycobacterium tuberculosis compartmentalized in the lungs and blood of HIV-infected individuals in Uganda
(Makerere University, 2022)
Introduction: Mycobacterium tuberculosis (MTB), particularly clinical strains present a genomic diversity that ranges from several single nucleotide polymorphisms (SNPs) to insertions and deletions (INDELS). This study ...
Effect of vitamin d binding protein gene polymorphisms and vitamin d bioavailability on cathelicidin expression in tuberculosis infection and disease
(Makerere University, 2023-01)
Background: The human antimicrobial peptide cathelicidin (LL-37) is involved in host innate immunity by the after activation of Toll-like receptors (TLRs), resulting in direct killing of Mycobacterium tuberculosis (MTB). ...
Insights into genomic variations between Mycobacterium tuberculosis compartmentalized in the lungs and blood of HIV-infected individuals in Uganda
(Makerere University, 2022-08-19)
Introduction: Mycobacterium tuberculosis (MTB), particularly clinical strains present a
genomic diversity that ranges from several single nucleotide polymorphisms (SNPs) to insertions
and deletions (INDELS). This study ...
Patient single nucleotide polymorphisms assiocated with Mycobacterium tuberculosis genotypes in Ugandan population
(Makerere University, 2022-12)
Uganda is one of the 30 World Health Organization-designated countries with a high burden of TB/HIV, with three main dominant genotypes that cause tuberculosis. Recent studies have shown that the M. tuberculosis Uganda ...
Detection of clinically relevant respiratory viruses and their temporal dynamics in sputum of tuberculosis patients on anti-TB drugs at Naguru Hospital, Kampala, Uganda
(Makerere University, 2024)
Background
Tuberculosis is one of the leading infectious causes of death in the world, with nearly 10 million new cases diagnosed each year, resulting into an estimated 1.3 million deaths(1). The relationship between M. ...