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Patient single nucleotide polymorphisms assiocated with Mycobacterium tuberculosis genotypes in Ugandan population
(Makerere University, 2022-12)
Uganda is one of the 30 World Health Organization-designated countries with a high burden of TB/HIV, with three main dominant genotypes that cause tuberculosis. Recent studies have shown that the M. tuberculosis Uganda ...
A comparison of frequencies and function of myeloid derived suppressor cells (MDSCS) IN TB/HIV co-infected and HIV mono-infected individuals in Uganda
(Makerere University, 2023)
Background
Myeloid-derived suppressor cells (MDSC) encompass a subset of myeloid cells, which suppress both innate and adaptive immune functions. These cells negatively regulate the immune function either by arginine ...
Growth patterns and survivability of the different mycobacterium tuberculosis sub lineages predominant in peri urban Kampala
(Makerere University, 2014-05)
Background: Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB) infects over 2 billion people world-wide with the vast majority of deaths from TB in the developing world. Strains of MTB vary in ...
A comparison of Ubiquitin E3 ligases as surrogate markers for T cell Anergy in active TB
(2024-10-24)
Background: Globally, there is an estimated 1.2 million TB-related deaths among HIV-negative people with active TB. Previous studies using ex-vivo and animal models indicate that CD4+ T cell unresponsiveness to Mtb, which ...