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The relationship between the haemolytic crises in sickle cell anaemia, and the deficiency of the red cell enzyme glucose-6-phosphate dehydrogenase

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dc.contributor.author Kibuka, musoke
dc.contributor.author Mukkaanya, Moses E
dc.date.accessioned 2013-07-02T08:18:35Z
dc.date.available 2013-07-02T08:18:35Z
dc.date.issued 1975-01
dc.identifier.uri
dc.identifier.uri http://hdl.handle.net/10570/1461
dc.description A dissertation submitted for the award of the degree of Master of Medicine in Paediatrics of Makerere University en_US
dc.description.abstract Seventy-two patients with proved haemoglobin SS were studied in respected of their haemoglobin, reticulocyte counts, serum bilirubin and their Glucose-6-phosphate dehydrogenase values in international units per gram of Haemoglobin. Of the whole group 18% were found to be deficient in the enzyme. A retrospective study of these patients was carried out to see if those who were deficient in the enzyme are those who experienced haemolytic crises. Records at the Sickle Cell Clinic did not reveal any well documented case of a haemolytic crisis having occurred in any of these patients, a few had clinical evidence of increased haemolysis. One patient who had evidence of increased haemolysis was discussed in detail and was thought to be Glucose-6-Phosphate Dehydrogenase deficient, and it was suggested that the increased haemolysis was precipitated by ingestion of aspirin. It has been suggested that a detailed study if those patients was Sickle Cell anaemia and Glucose-6-Phopsphate Dehydrogenase deficiency is required to establish the occurrence of haemolytic crises and find the precipitating factors. en_US
dc.language.iso en en_US
dc.subject Haemolytic crises en_US
dc.subject Hemolytic anemia en_US
dc.subject Sickle cell anemia en_US
dc.subject Red cells en_US
dc.subject Red cell enzyme en_US
dc.subject Erythrocytes en_US
dc.subject Glucose-6-phosphate dehydrogenase en_US
dc.subject Glucose-6-phosphate dehydrogenase deficiency en_US
dc.subject Hemoglobin en_US
dc.title The relationship between the haemolytic crises in sickle cell anaemia, and the deficiency of the red cell enzyme glucose-6-phosphate dehydrogenase en_US
dc.type Thesis, masters en_US


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