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c-erb-2 oncoprotein over-expression in breast cancer and its relationships to histology type and grade in a Uganda population

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dc.contributor.author Nalwoga, H.
dc.contributor.author Odida, M.
dc.contributor.author Wabinga, H.
dc.date.accessioned 2013-02-20T08:25:25Z
dc.date.available 2013-02-20T08:25:25Z
dc.date.issued 2006-08
dc.identifier.citation Nalwoga, H., Odida, M., & Wabinga, H. (2006). c-erb-2 oncoprotein over-expression in breast cancer and its relationships to histology type and grade in a Uganda population. East African Medical Journal. 83(8): 63-68 en_US
dc.identifier.uri
dc.identifier.uri http://hdl.handle.net/10570/1104
dc.description.abstract Objective: To evaluate c-erbB-2 oncoprotein over expression in breast cancer patients of Kyadondo county and also relate this oncoprotein to histological type and grade of the tumour. Design: Cross-sectional study. Setting: Pathology Department, Faculty of Medicine, Makerere University. Subjects: Seventy two breast cancer patients who were among the 174 entered in survival study had their paraffin breast tissue blocks retrieved from archives of Pathology Department and had their c-erbB-2 determined by peroxidase-labeled streptavidin-biotin immunohistochemical method. Results: c-erbB-2 oncoprotein was over expressed in 33.3% of the tumours and correlated positively with histological grade (p = 0.007). TH oncoprotein over expression was not restricted to any particular histological type and there was no association with age of patient. Conclusion: The over expression of c-erbB-2 oncoprotein observed in one third of breast cancer patients of this African population could partly explain the observed poor survival rate reported in this community. en_US
dc.language.iso en en_US
dc.publisher East African Medical Journal en_US
dc.subject Uganda en_US
dc.subject Breast cancer en_US
dc.title c-erb-2 oncoprotein over-expression in breast cancer and its relationships to histology type and grade in a Uganda population en_US
dc.type Other en_US


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